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. Author manuscript; available in PMC: 2014 Jan 22.
Published in final edited form as: Nat Protoc. 2010 Nov 4;5(12):1867–1887. doi: 10.1038/nprot.2010.139

Figure 3. Photodegradable acrylate monomer synthetic scheme.

Figure 3

Synthetic route for preparing photodegradable acrylate. Reagents and conditions: (reaction a) DMF, ethyl-4-bromobutyrate, Ar, K2CO3; (reaction b) HNO3, ∼ 5 °C → ∼ 32 °C; (reaction c) EtOH, Ar, NaBH4, 38 °C; (reaction d) DI H2O, TFA, ∼ 90 °C; (reaction e) Ar, DCM, TEA, AC, 0 °C → room temperature; (reaction f) acetone, DI H2O. Each chemical compound is numbered (Compounds 1-6) for its identification in the experimental procedure.