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. 2014 Jan 13;14:16. doi: 10.1186/1471-2407-14-16

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Copyright © 2014 Thangapazham et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Expression of predicted NKX3.1 target genes in response to NKX3.1 inhibition. (A) Depletion of NKX3.1 results in increases in mRNA levels of wild type TMPRSS2, TMPRSS2-ERG fusion (T2-ERG), HDAC9, RUNX1, NFкB and JARID. In contrast, robust reduction of CFTR levels is apparent in response to NKX3.1 inhibition. (B) Rescue of ERG and its downstream function by NKX3.1 inhibition (NKX3.1 siRNA) is shown by nuclear localization of ERG (upper panel), sharp increases in ERG protein levels (lower panel), and by the depletion of the ERG-downstream target prostein (SLC45A3). Schematic depiction of the negative regulatory role of NKX3.1 in the context of TMPRSS2-ERG (T2-ERG) gene fusion (inset).