Table 3.
Survival time of rats bearing F98 gliomas following CED of carboplatin (10 μg × 2) and 15 Gy X-irradiation (7.5 Gy × 2)
| |
Survival times (days)
c
|
% Increased life span |
||||
|---|---|---|---|---|---|---|
| Treatment group a | N | Mean ± SE | Median | Range | Mean | Median |
| Untreated |
5 |
24.6 ± 1.1 |
25 |
21–28 |
0 |
0 |
| X-irradiationb |
4 |
30.0 ± 1.9 |
30 |
28–32 |
22 |
20 |
| CED of carboplatin |
5 |
46.8 ± 7.5 |
43 |
33–67 |
90 |
72 |
| CED of carboplatin + X-ray | 12 | 82.1 ± 15.5 | 54.5 | 35 > 180(3) | 234 | 118 |
aStereotactic intracerebral implantation of 103 F98 glioma cells was carried out on d. 0. Carboplatin (10 μg in 10 μL) was administered by convection enhanced delivery at a flow rate of 0.33 μL/min. for 30 min on day 13th and 15th.
bAnimals received 15 Gy of 6 MV LINAC X-rays, delivered in two 7.5 Gy fractions on day 14th and 16th.
cSurvival of >180 d. indicates that these animals have been cured of their tumors. The number in parenthesis indicates the number of long-term survivors.