Figure 3.

Functional magnetic resonance imaging results at Day –1. The upper panel depicts the regions of interest used on orthogonal maximum intensity projections (“glass brains” viewed from the right (left projection), from behind (middle) and from above (right). The lower panels show the significant (p<.05, uncorrected for display) areas of activation when contrasting viewing of high-calorie to low-calorie food images at Day –1. This contrast used the placebo and GSK1521498 treatment groups combined and shows activity across key regions of reward circuitry. Full details of the activation foci are presented in Table 1. Areas of significant activation are rendered onto a standard template image in Montreal Neurological Institute space with sections chosen at the coordinates most appropriate to display the key activations. This activation map was used as a mask to constrain subsequent analysis exploring condition-specific effects of GSK1521498.