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. 2014 Jan 15;75(2):115–123. doi: 10.1016/j.biopsych.2013.07.013

Figure 2.

Figure 2

High impulsivity in rats is associated with a significant reduction in glutamate decarboxylase (GAD)65/67, microtubule-associated protein 2 (MAP2), and spinophilin (Spinoph) in the left nucleus accumbens (NAcb) core but not right NAcb core. (A) Representative immunoreactive bands from samples of the left and right NAcb core in low-impulsive (LI) and high-impulsive (HI) rats. (B) Densitometric quantification (relative optical density [R.O.D.] expressed as a % of the mean value of LI rats) of left NAcb core revealed a significant reduction of GAD65/67 (t9 = 3.48, **p < .01), MAP2 (t9 = 2.34, *p < .05), and spinophilin (t9 = 2.43, *p < .05) in HI rats compared with LI rats. Data are expressed as mean ± SEM. (C) Densitometric analysis of samples from the right NAcb core revealed no significant differences in GAD65/67, MAP2, and spinophilin (GAD65/67; t9 =1.66, p = .13). (D–F) Correlation between impulsivity scores and the relative optical density of GAD65/67 ([D]r = −.71, p < .01), MAP2 ([E]r = −.66, p < .05), and spinophilin ([F]r = −.47, p = .074) in left NAcb core. Insert graph shows equivalent data for the right NAcb core.