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. 2013 Oct 4;17(1):221–234. doi: 10.1007/s10456-013-9390-5

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© The Author(s) 2013

Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 6 — Perivascular cell coverage of tumor vessels is inhibited by DKK1 and enhanced by DKK2. Sections of B16F10 melanoma tumors generated in DKK1 Tg, DKK2 Tg, and wild-type mice were stained with anti-CD31 and anti-smooth muscle actin (SMA) antibodies. Nuclei were stained with DAPI. SMC coverage is presented (a) and quantified as the ratio of SMA⁺ area to CD31⁺area (b). Sections of tumors generated in DKK1 Tg, DKK2 Tg, and wild-type mice were stained with anti-CD31 and anti-NG2 (pericyte-specific) antibodies. Pericyte coverage is presented (c) and quantified as the ratio of NG2⁺ area to CD31⁺ area (d). Nuclei were stained with DAPI. Data are mean ± SD (*p < 0.05; **p < 0.01)