Fig. 1.

Structure of ivermectin bound to a glutamate-gated chloride channel. The GluCl shown is formed of GLC-1 subunits (Cully et al., 1994). Two views are shown. (A) The view is from the side of the receptor, looking parallel with the membrane. (B) Looking down on the binding site from the outside of the cell, with the extracellular part of the GluCl removed. The binding site is between the M3 helix of the (+) subunit and M1 of the (−) subunit.

© 2011 Reprinted by permission from Macmillan Publishers Ltd.: Nature 274, 54. Copyright 2011