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. 2013 Dec;75:8–14. doi: 10.1016/j.curtheres.2013.04.001

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© 2013 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig. 3 — Combination effect of Rauwolfia vomitoria extract (Rau) and carboplatin (Cp) in ovarian cancer cells. (A) Dose-response curves. Ovarian cancer cells were treated with Cp (dotted line) and the combination of Cp and Rau (Cp + Rau, solid line) for 48 hours. The molar ratio of the combination was IC_50Rau:IC_50Cp. (B) Combination index (CI) across the fraction affected (f_a). The molar ratio of Rau:Cp was IC_50Rau:IC_50Cp. A CI value >1 indicates antagonism, a CI value of 1 indicates additive effect, and a CI value <1 indicates synergy. (C) The dose-reduction index (DRI) across the f_a for Cp when Rau was combined.