Table II.
Rotarod and accelerod results with or without (baseline) drugs. The data are presented as median (minimum–maximum).
| Variable | Midazolam (n = 8) | Dexmedetomidine (n = 8) | Control (n = 8) |
|---|---|---|---|
| Baseline rotarod test (sec) | |||
| 5 rpm | 300 (247–300) | 300 (288–300) | 300 (149–300) |
| 10 rpm | 300 (136–300) | 300 (148–300) | 255 (131–300) |
| 20 rpm | 180 (90–300) | 175 (75–300) | 184 (94–300) |
| 30 rpm | 45 (28–156) | 39 (15–129) | 45 (17–142) |
| 40 rpm | 17 (10–43) | 15 (10–35) | 18 (10–37) |
| Rotarod test with drugs (sec) | |||
| 5 rpm | 224 (145–300)† | 141 (110–160)* | 300 (187–300) |
| 10 rpm | 198 (68–300)† | 109 (99–126)* | 300 (189–300) |
| 20 rpm | 144 (98–300)*,† | 58 (20–117)* | 215 (91–300) |
| 30 rpm | 38 (23–179)*,† | 10 (10–20)* | 191 (71–240) |
| 40 rpm | 14 (10–57)† | 9 (6–16)* | 45 (10–102) |
| Baseline Accelerod test (sec) | |||
| 4 (min) | 91 (21–219) | 137 (31–203) | 136 (96–195) |
| 10 (min) | 142 (58–300) | 184 (57–266) | 225 (167–277) |
| Accelerod test with drugs (sec) | |||
| 4 (min) | 102 (92–125)* | 59 (13–94)* | 154 (111–198) |
| 10 (min) | 163 (136–359)† | 129 (113–136)* | 223 (79–390) |
⁎
Versus control (P < 0.016).
†
Versus dexmedetomidine ( P < 0.016).