Table 1.
Top five predicted TFs for liver, retina and B cell
| TF | Score | Known functions in the corresponding tissue |
|---|---|---|
| A. Liver | ||
| Hnf4a |
2.22 |
Essential for maintaining hepatic gene expression and lipid homeostasis
[41] |
| Rara |
1.90 |
Important in maintaining liver homeostasis, and its disruption is linked to hepatocarcinogenesis
[57] |
| Nr2f2 |
1.56 |
Expressed in liver, and known to regulate liver-specific genes
[58] |
| Rxra |
1.45 |
Important role in liver metabolism
[59] |
| Tcf7 |
1.44 |
Downstream regulator in Wnt signaling which is critical in liver physiology and pathology
[60] |
| B. Retina | ||
| Crx |
4.28 |
Regulates photoreceptor gene expression
[40] |
| Pitx3 |
4.26 |
Required for normal retina formation in Xenopus and zebrafish
[61,62] |
| E2F3 |
4.06 |
Involved in retina progenitor cell development
[63] |
| Pitx2 |
3.92 |
Pitx2-deficient mouse exhibits ocular abnormalities
[64] |
| Gsc |
3.89 |
Unknown function in retina. |
| C. CD19+ B cell | ||
| Sfpi1 |
2.09 |
Essential regulator of B-cell differentiation
[65] |
| Pou2f2 |
2.08 |
Required for T-cell independent B cell activation
[66] |
| Spic |
1.98 |
Promotes B cell differentiation
[67] |
| Pou2f3 |
1.94 |
Unknown function in B cell, but has almost the same binding preference as Pou2f2 |
| Elf4 | 1.70 | Regulates proliferation of B cells [68] |