Figure 2.

A single FS burst at 50 Hz evokes GABA_A- and GABA_B-receptor-activated currents. A, Sample traces of FS neuron firing and postsynaptic GABA_A (blue) and GABA_B (red) currents. FS action potentials were elicited with 10–5 ms suprathreshold depolarizing steps delivered at 50 Hz. Bath application of bicuculline allowed the isolation of the GABA_B current. Coapplication of bicuculline and CGP52432 abolished both GABA_A-and GABA_B-mediated currents (black). B, Average amplitude of GABA_A and GABA_B receptor mediated currents. C, Time course of changes in IPSP amplitude following bath perfusion of bicuculline and bicuculline + CGP52432. Gray bars on sample traces in A indicate the site of measurements of peak currents. Data are presented as mean ± SE.