Figure 4.

Impact of candidate gene list size and purity on sensitivity and specificity of CSEA. A, Box-and-whisker plots illustrating the distribution of CSEA p values (log base 10 scale, y-axis) for rods from retinopathy gene lists sampled at various sizes (100 samplings per size). B, From random subsets of retinopathy gene lists mixed with random sets of nonretinopathy genes. The x-axis (purity) indicates what fraction of the list derives from the original retinopathy set (100 samplings per purity). A pSI threshold of <0.01 is shown here. Results are substantially similar across all pSI thresholds from 0.05 to 0.0001 (data not shown).