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. 2013 May 27;32(49):5522–5530. doi: 10.1038/onc.2013.189

Figure 5.

Figure 5

Telomere-associated DNA damage and HR in freshly EBV-infected cells. (a) Representative immunofluorescence-FISH (IF-FISH) micrographs illustrating the presence of APBs in EBV-infected primary B cells. (b) Mean±s.e. of cell containing at least two or more APBs in EBV-infected and mitogen-stimulated blasts. At least 25 nuclei per each condition and time point were scored in three independent experiments. *P<0.05. (c) Representative micrographs illustrating the occurrence of telomere-sister chromatid exchange in EBV-infected cells. Chromosome orientation (CO)-FISH was performed with the telomere strand-specific probes TelC (leading strand template, red) and TelG (lagging strand template, green). Telomere sister chromatid exchange is visualized by colocalization of red and green signals on the same telomere (arrows). (d) Mean±s.e. of telomere-sister chromatid exchange-positive chromosomes. Approximately 1000 metaphase chromosomes were score in six newly established and six old LCLs in two independent experiments. *P<0.05.