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Interactions between SIRT1 and transcription factors c-MYC and E2F1. Solid lines between SIRT1 and c-MYC indicated are interactions from Yuan, Minter-Dykhouse et al. 2009 forming a negative feedback loop, while dashed lines are findings related to SIRT1 and c-MYC from Menssen, Hydbring et al. 2012.
