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. Author manuscript; available in PMC: 2014 Jan 22.
Published in final edited form as: Mol Cell. 2011 May 20;42(4):489–499. doi: 10.1016/j.molcel.2011.04.015

Figure 6. A working model: A high local concentration of pADPr at miRNA complex results in relief of miRNA silencing.

Figure 6

Upon stress, multiple proteins including all Argonaute family members and PARP-13.1/2 complex are increasingly modified by pADPr. Such increase in poly(ADP-ribosylation) during stress could be due to increase in PARP activity and/or decrease in PARG activity (dotted line). High concentration of pADPr near the Argonaute/miRNA complex might disrupt electrostatic interaction or cause steric hindrance for effective miRNA silencing. Similar relief of miRNA silencing is also observed upon overexpression of PARP-13 or, conversely, upon knockdown of PARG.