Figure 1.
The Biguanide Drugs Phenformin and Metformin Decelerate Aging in C. elegans
(A and B) Metformin (A) and phenformin (B) extend lifespan in a dose-dependent manner. Phenformin alters fecundity and reduces body size (see Figures S1A–S1D).
(C) Phenformin (4.5 mM) does not increase lifespan in the presence of 50 mM metformin, consistent with similar mechanism of drug action.
(D) Metformin decreases the exponential increase in age-related mortality (for survival curve see Figure S1E).
(E) Later-life administration (day 8) of metformin increases lifespan at lower concentrations (25, but not 50 or 100 mM).