SPM{t} maps of voxelwise morphometric interactions in healthy subjects between age and COMT genotype. (A) GM density differences increasing with age (FWE p < 0.05) and (B) GM volume differences reducing with age (p < 0.001 unc.). Peaks of interest are indicated by the red arrows. (C) GM densities in premotor cortex (MNI x,y,z = −12 −8 71) are plotted against age for ValVal (red), ValMet (green) and MetMet (black) groups. (D) GM volume in the left frontal operculum/insula (MNI x,y,z = −33, 28, 1) are plotted against age for ValVal (red), ValMet (green) and MetMet (black) groups.