Table 1. Correlation of FER kinase expression with clinicopathological and molecular features of invasive breast cancer.
| Feature | N |
FER expression |
||
|---|---|---|---|---|
| Low (0-1+) N (%) | High (2-3+) N (%) | P-value | ||
| Histological type | ||||
| Invasive ductal cancer | 320 | 171 (53.4) | 149 (46.6) | |
| Invasive lobular cancer | 126 | 78 (61.9) | 48 (38.1) | |
| Other | 39 | 23 (59.0) | 16 (41.0) | 0.250 |
| Histological grade | ||||
| 1 | 88 | 63 (71.6) | 25 (28.4) | |
| 2 | 171 | 110 (64.3) | 61 (35.7) | |
| 3 | 219 | 94 (42.9) | 125 (57.1) | <0.001 |
| MAI (per 2 mm2) | ||||
| ⩽12 | 239 | 164 (68.6) | 75 (31.4) | |
| ⩾13 | 246 | 108 (43.9) | 138 (56.1) | <0.001 |
| Tumour size (cm) | ||||
| ⩽2 | 208 | 134 (64.4) | 74 (35.6) | |
| >2 and ⩽5 | 220 | 106 (48.2) | 114 (51.8) | |
| >5 | 49 | 29 (59.2) | 20 (40.8) | 0.003 |
| Lymph node status | ||||
| Negative | 227 | 133 (58.6) | 94 (41.4) | |
| Positive | 231 | 127 (55.0) | 104 (45.0) | 0.435 |
| Invasive lobular carcinomas | ||||
| Classical | 34 | 33 (97.1) | 1 (2.9) | |
| Pleomorphic | 56 | 17 (30.4) | 39 (69.6) | <0.001 |
| BRCA1 | ||||
| Sporadic | 459 | 266 (58.0) | 193 (42.0) | |
| Mutation carrier | 24 | 6 (25.0) | 18 (75.0) | 0.002 |
| Perou/Sorlie classification | ||||
| Luminal | 391 | 234 (59.8) | 157 (40.2) | |
| HER2 driven | 22 | 10 (45.5) | 12 (54.5) | |
| Basal/TN | 72 | 28 (38.9) | 44 (61.1) | 0.003 |
| ER | ||||
| Negative | 104 | 44 (42.3) | 60 (57.7) | |
| Positive | 381 | 228 (59.8) | 153 (40.2) | 0.001 |
| PR | ||||
| Negative | 200 | 106 (53.0) | 94 (47.0) | |
| Positive | 284 | 165 (58.1) | 119 (41.9) | 0.266 |
| HER2 | ||||
| Negative | 435 | 246 (56.6) | 189 (43.4) | |
| Positive | 49 | 25 (51.0) | 24 (49.0) | 0.460 |
| EGFR | ||||
| Negative | 393 | 233 (59.3) | 160 (40.7) | |
| Positive | 83 | 34 (41.0) | 49 (59.0) | 0.002 |
Abbreviations: EFGR, epidermal growth factor receptor; ER, oestrogen receptor; HER2, human epidermal growth factor receptor 2; MAI, mitotic activity index; PR, progesterone receptor; TN, triple negative.
Statistical significance estimated by χ2-test.
Statistically significant P-values are indicated in bold.