Table 3.

Results of mixed effect models for the outcomes %^* ventricular, total brain and hippocampal volume change: interaction effects of age and postmortem pathologies, APOE ε4 and cognitive status.

	% Ventricular Coefficient (SE), p-value	% Total Brain Coefficient (SE), p-value	% Hippocampal Coefficient (SE), p-value
Age	0.08(0.02); <0.0001 a	−0.28 (0.07); 0.0001 a	−0.0006(0.0004); 0.14
Age* mild cognitive impairment	0.009 (0.005);	−0.07 (0.02);	0.00002 (0.0002);
Reference: no cognitive impairment	0.04	0.004a	0.89
Age* dementia	0.03 (0.007);	−0.08 (0.04);	−0.000007 (0.0002);
Reference: no cognitive impairment	<0.0001a	0.018	0.97
Age* Braak 5–6	0.06(0.02);	−0.11(0.09);	0.0005 (0.0004;)
(Reference: Braak none, 1 or 2)	0.015a	0.2	0.26
Age * Braak 3–4	−0.004(0.02);	−0.09 (0.06);	0.0003 (0.0003);
(Reference : Braak none, 1 or 2)	0.79	0.11	0.35
Age* CERAD moderate or frequent	0.05 (0.02);	−0.05 (0.06);	−0.0002 (0.0003);
(Reference: CERAD none or sparse)	0.001 a	0.39	0.48
Age* ε4 present	0.1(0.02);	−0.12 (0.08);	−0.0005 (0.0004);
(Reference: no ε4 present)	<0.0001 a	0.11	0.18
Age * gross infarct present	0.07 (0.02);	−0.12 (0.06);	−0.0004 (0.0003);
(Reference: no gross infarct present)	<0.0001 a	(0.04)	0.17
Age* Lewy Bodies present	−0.008 (0.02);	0.01 (0.07);	−0.0001 (0.0004);
(Reference: no Lewy Bodies present)	0.65	0.84	0.73
Age* Amyloid Angiopathy present	0.01 (0.01);	−0.13 (0.06);	−0.0008 (0.0003);
(Reference: no amyloid angiopathy)	0.44	0.03	0.009
Age* microinfarcts 2 or more	−0.013 (0.02);	−0.03 (0.07);	−0.0003 (0.0003);
(Reference: no microinfarcts)	0.45	0.63	0.39
Age* microinfarcts one	−0.005 (0.02);	−0.006 (0.08);	−0.0003 (0.0004);
(Reference: no microinfarcts)	0.82	0.94	0.43

In all models, duration (time from first MRI to death) and age at death were controlled.

^*proportion of intracranial volume

^aSignificant using Bonferroni multiple comparison adjusted p-value (0.017)