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. 2013 Dec 3;175(1):41–48. doi: 10.1111/cei.12209

Figure 2.

Figure 2

Effects of tumour necrosis factor (TNF)-α blockade on the frequencies of antigen-specific Th1/Th17 cells in spleen and central nervous system (CNS). (a) Results of enzyme-linked immunospot (elispot) assays in phosphate-buffered saline (PBS) (n = 12)-, Humira® (n = 8)- and Enbrel®-treated mice (n = 8) for interferon (IFN)-γ (**P < 0·01, rank sum test) and interleukin (IL-17 (*P < 0·05, rank sum test) in the spleen. (b) Results of IFN-γ/IL-17 elispot assays in PBS (n = 13)-, Humira® (n = 5)- and Enbrel®-treated mice (n = 8 IFN-γ; n = 7 IL-17) in the spinal cord.