Table 1.

Central nervous system (CNS) histopathology in phosphate-buffered saline (PBS)-, Humira®- and Enbrel®-treated mice

Treatment	No. of mice	Clinical score	Degree of inflammation	Lesion size [%]	No. of intact axons/mm2	No. of axolytic axons/mm2	No. of demyelinated axons/mm2
PBS	4	2·50 ± 0·41	2·00 ± 1·08	31·92 ± 20·37	2·17 × 105 ± 2·75 × 104	3·39 × 104 ± 3·51 × 103	6·17 × 103 ± 6·64 × 103
Humira®	3	2·92 ± 0·14	2·33 ± 0·94	29·73 ± 10·36	1·40 × 105 ± 1·40 × 105	5·21 × 104 ± 2·83 × 103	5·58 × 105 ± 9·33 × 105
Enbrel®	4	2·69 ± 0·13	2·88 ± 0·85	55·76 ± 25·47	1·60 × 105 ± 1·11 × 105	4·06 × 104 ± 3·72 × 104	4·96 × 103 ± 5·02 × 103