Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jan 22;4:195. doi: 10.3389/fendo.2013.00195

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Miller and Takahashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model of the interaction between the daily timing signal and the ovarian signal on GnRH release. AVP is rhythmically transcribed in the SCN and forms the basis for the strong neural daily timing signal from the SCN. On the day of proestrus, estradiol produced by the developing follicles in the ovary upregulates expression of hypothalamic AVP and VIP receptors and primes kisspeptin neurons to become more sensitive to the SCN-derived signal. The end result is an increase in excitatory input to GnRH neurons, elevated GnRH release, and a subsequent surge in LH.