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Propolis/CAPE epigenetically modulates ER−α and EGFR in MDA-231 (TNBC) cells: MDA-231 cells were treated with and without CAPE or with control LBH 589. ER−α is upregulated in the presence of CAPE as seen by immunofluorescence (top panel) and RT-PCR (bottom panel) (Figure 5A). CAPE and propolis (normalized for CAPE content) decrease EGFR protein expression in a concentration-dependent manner in MDA-231 cells (Figure 5B).
