Figure 2.

Effect of skm-gp130 on development of cancer-induced cachexia. LLC tumor cells were implanted in 8-wk-old wild-type BL/6 and skm-gp130^−/− (skm-gp130) mice. Tumors were allowed to grow until 13 wk of age. A) Skm-gp130 expression changed with LLC-induced cachexia in wild-type and skm-gp130 mice in the gastrocnemius. ND, not detected. B) Tumor mass was measured at the time of death. C, D) Percentage change in body weight (BW) from genotype control (C) and percentage change in gastrocnemius muscle mass (D) were calculated from weights collected at the time of death. All values are means ± sem. ***P < 0.05 vs. BL/6 group.