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Aldosterone receptor antagonism eliminates QT prolongation arising from Kcne3 deletion. A) Representative (of n=9–10 mice) baseline ECGs recorded from 9-mo-old Kcne3+/+ and Kcne3−/− mice pretreated with spironolactone. B) Mean ECG parameters of 9-mo-old Kcne3+/+ (n=9) and Kcne3−/− (n=10) mice pretreated with spironolactone.
