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. 2014 Feb;28(2):923–934. doi: 10.1096/fj.13-240879

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This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) (http://creativecommons.org/licenses/by/3.0/deed.en_US) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — SNP rs4253238 is in LD with other KLKB1 SNPs. A) LD plot of the GWAS identified SNP rs4253238 identifies a block of LD between this SNP and other SNPs present in the KLKB1 gene, in the control/asthma data set (n=584). B) LD plot generated with Haploview, utilizing HapMap data selected for the CEU (Utah residents with northern and western European ancestry) population, confirms the presence of a block of LD for SNP rs4253238 with SNPs in the 5′ region of the KLKB1 gene. Numbers identify the R² values up to a maximum of 100. The color scheme denotes the level of LD as defined by D′. Similar plots identify no LD with regions downstream of rs4253238 (data not shown).