Table 1.

Induction over Time

	siNT	siSik1	siCrtc
Sik1	↑↑ p = 0.0000015	x p = 0.41	↑ p = 0.00979
Per1	↑↑ p = 0.000022	↑↑↑ p = 0.000093	x p = 0.06
Egr1	↑↑ p = 1.2 × 10−10	↑↑↑ p = 4.2 × 10−14	x p = 0.18
Nr4a1	↑↑ p = 0.000143	↑↑↑ p = 0.0000057	↑ p = 0.00755

Induction as measured by change in expression levels by one-way ANOVA across time. Expression levels of indicated transcripts in NIH 3T3 cells treated with siSik1, siCrtc, or siNT were analyzed for change over a 3 hr time course (Figure 2D–2I), p value calculated by one-way ANOVA, indicated in small print in each cell, n = 4. Number of ↑ indicate expression levels, with ↑↑ indicating control levels, ↑↑↑ indicates increase compared to control, ↑ indicates decreased induction compared to control and x indicating no significant induction.