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. Author manuscript; available in PMC: 2014 Nov 27.
Published in final edited form as: J Am Chem Soc. 2013 Nov 13;135(47):17659–17662. doi: 10.1021/ja4066317

Figure 1.

Figure 1

A) Assembly of the nanogate-based amplifier. The capping agent is synthesized using a Cu catalyzed azid-alkyne coupling reaction. The green knot represents the enzyme molecule that is trapped in the pore. B) The mechanism of the self-amplifying chemical sensing process. The size selectivity of the nanogate enables separation of the substrate (blue cubes) and the enzyme. A small analyte molecule (blue ball) actuates the nanogate, which opens the access to the enzyme and fluorescent products are generated catalytically.