Fasting blood glucose and glucose tolerance profiles in 12-week-old wild type and rAAV8-treated G6pc−/− mice. (A) Fasting blood glucose profiles. (B) Blood glucose levels following a 24-hour fast. (C) Glucose tolerance profiles. GPE-high (n = 6), high dose rAAV8-GPE-treated (○); miGPE-high (n = 6), high dose rAAV8-miGPE-treated (●); GPE-low (n = 6), low dose rAAV8-GPE-treated (□); miGPE-low (n = 6), low dose rAAV8-miGPE-treated (∎) G6pc−/− mice; (+/+), wild type mice (n = 24) (▾). Data are mean ± SEM. *P < 0.05, **P < 0.005.