. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: Mol Genet Metab. 2013 Jun 25;110(3):275–280. doi: 10.1016/j.ymgme.2013.06.014

Table 1.

Human G6PC genome distribution and mRNA expression in 12-week-old high dose rAAV-GPE-treated G6pc−/− mice

Tissue	Human G6PC Copy number/μg genomic DNA	Human G6PC mRNA relative to RpI19 mRNA × 10⁵
Wild type tissues, no transgene (n = 6)	8 ± 2	8 ± 1
Liver, −/−/rAAV8-GPE (n = 6)	94,440 ± 7,624 (100)	62740 ± 4445 (100)
Kidney, −/−/rAAV8-GPE (n = 6)	2,429 ± 626 (2.57)	22 ± 5 (0.033)
Intestine, −/−/rAAV8-GPE (n = 6)	601 ± 124 (0.64)	9 ± 1
Brain, −/−/rAAV8-GPE (n = 6)	121 ± 23 (0.12)	8 ± 1
Testis, −/−/rAAV8-GPE (n = 6)	25 ± 8 (0.02)	9 ± 1
Ovary, −/−/rAAV8-GPE (n = 6)	7 ± 2	9 ± 1

Data are means ± SEM. The values of wild type tissues, which contain no transgene, were the mean ± SEM of liver, kidney, intestine, brain, testis, and ovary. Numbers in parentheses are % of liver value.