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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Circ Cardiovasc Genet. 2013 Feb;6(1):118–131. doi: 10.1161/CIRCGENETICS.110.959387

Figure 8.

Figure 8

Constructing a family history is a dynamic process that unfolds over time. A, At diagnosis, this patient (arrow) had no known history of HCM but reported suspicious cardiac features in three family members (III-2, III-4, and IV-3). B, Review of family medical records dramatically altered the original history, showing those three family members to have HCM and the patient’s unaffected sister (III-1) to be an obligate carrier (vertical line). C, The patient’s mother then reported that her sister (II-9) carried a diagnosis of HCM. This definitively localized the disease to the maternal side of the family, revealing the patient’s mother (II-4) as another obligate carrier. Circles indicate females; squares, males; slash, deceased. HCM = hypertrophic cardiomyopathy.