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. Author manuscript; available in PMC: 2014 Jul 5.
Published in final edited form as: J Org Chem. 2013 Jun 18;78(13):6412–6426. doi: 10.1021/jo4007893

Figure 2. Hypothetical Biosynthesis of Nocardicin A.

Figure 2

NocA and NocB together contain five modules which are predicted to produce the pentapeptide L-pHPG-L-Arg-D-pHPG-L-Ser-L-pHPG (5) which then may go on to form the first β-lactam containing intermediate nocardicin G (6) and ultimately nocardicin A (4).