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. Author manuscript; available in PMC: 2014 Jul 5.
Published in final edited form as: J Org Chem. 2013 Jun 18;78(13):6412–6426. doi: 10.1021/jo4007893

Figure 3. Chemical Equilibrium of Spontaneous Racemization of Nocardicin GSNAC to epi-Nocardicin G-SNAC.

Figure 3

a) HPLC analysis of chemical racemization of the α-hydrogen of the C-terminal pHPG in nocardicin G-SNAC in 50 mM KiPO4 buffer at pH 7.5 as a function of time. b) Extent of chemical epimerization was quantified and plotted as a one-phase exponential decay. The rate of chemical epimerization was measured to be 5.5(2) × 10−4 sec−1 (k1 + k2).