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Tumorsphere formation in HER2-overexpressing cancer cells in 3D culture system. (A) MCF7 WT cells did not form any tumorspheres while MCF7-HER2 formed tumor spheres stably after day 6 (B). Targeted knockdown of STAT3 cells failed to form any spheres (C). The formed spheres were counted from each well and presented as a graph (D).
