Table 2.
Selected genes downregulated in Th1Th17 vs. Th1
| Gene symbol | Fold change Th1Th17/Th1 | p-value | Gene title |
|---|---|---|---|
| XCL1 |
−7,53 |
0,001 |
Chemokine (C motif) ligand 1 |
| IL5 |
−3,35 |
0,010 |
Interleukin 5 (colony-stimulating factor, eosinophil) |
| KLRK1 |
−2,66 |
0,003 |
Killer cell lectin-like receptor subfamily K, member 1 |
| LAIR2 |
−2,57 |
0,004 |
Leukocyte-associated immunoglobulin-like receptor 2 |
| IL4 |
−2,47 |
0,013 |
Interleukin 4 |
| TIGIT |
−2,36 |
0,001 |
T cell immunoreceptor with Ig and ITIM domains |
| CDH1 |
−2,35 |
0,000 |
Cadherin 1, type 1, E-cadherin (epithelial) |
| IL17RB |
−2,33 |
0,005 |
Interleukin 17 receptor B |
| CXCL10 |
−2,31 |
0,046 |
Chemokine (C-X-C motif) ligand 10 |
| FCRL3 |
−2,30 |
0,048 |
Fc receptor-like 3 |
| IL-17RB |
−2,19 |
0,003 |
Interleukin 17 receptor B |
| SLAMF7 |
−2,08 |
0,027 |
SLAM family member 7 |
| PTK2 |
−2,01 |
0,000 |
PTK2 protein tyrosine kinase 2 |
| CXCR5 |
−2,00 |
0,013 |
Chemokine (C-X-C motif) receptor 5 |
| ZNF80 |
−1,96 |
0,008 |
Zinc finger protein 80 |
| CADM1 |
−1,89 |
0,037 |
Cell adhesion molecule 1 |
| CD109 |
−1,84 |
0,034 |
CD109 molecule |
| SERPINB6 |
−1,80 |
0,003 |
Serpin peptidase inhibitor, clade B, member 6 |
| PECAM1 |
−1,76 |
0,004 |
Platelet/endothelial cell adhesion molecule |
| NFIA |
−1,64 |
0,009 |
Nuclear factor I/A |
| TIAM2 |
−1,64 |
0,008 |
T-cell lymphoma invasion and metastasis 2 |
| BCL2L14 |
−1,63 |
0,032 |
BCL2-like 14 (apoptosis facilitator) |
| ACPL2 |
−1,58 |
0,013 |
Acid phosphatase-like 2 |
| IFI27 |
−1,57 |
0,026 |
Interferon, alpha-inducible protein 27 |
| CCL17 |
−1,54 |
0,019 |
Chemokine (C-C motif) ligand 17 |
| ALCAM |
−1,54 |
0,009 |
Activated leukocyte cell adhesion molecule |
| H1F0 |
−1,50 |
0,020 |
H1 histone family, member 0 |
| PLA2G4A |
−1,49 |
0,030 |
Phospholipase A2, group IVA |
| HTATIP2 |
−1,49 |
0,034 |
HIV-1 Tat interactive protein 2, 30 kDa |
| SMAD2 |
−1,48 |
0,027 |
SMAD family member 2 |
| ISYNA1 |
−1,48 |
0,026 |
Inositol-3-phosphate synthase 1 |
| ZNF827 |
−1,47 |
0,030 |
Zinc finger protein 827 |
| TAF15 |
−1,47 |
0,040 |
TBP-associated factor RNA polymerase II |
| GATA3 |
−1,46 |
0,015 |
GATA binding protein 3 |
| HLA-DOA |
−1,42 |
0,032 |
Major histocompatibility complex, class II, DO alpha |
| ZNF642 |
−1,40 |
0,025 |
Zinc finger protein 642 |
| GRK5 |
−1,39 |
0,041 |
G protein-coupled receptor kinase 5 |
| ZNF167 |
−1,38 |
0,022 |
Zinc finger protein 167 |
| AARS |
−1,37 |
0,021 |
Alanyl-tRNA synthetase |
| MARS |
−1,36 |
0,041 |
Methionyl-tRNA synthetase |
| ZNF107 |
−1,35 |
0,031 |
Zinc finger protein 107 |
| ZNF443 | −1,35 | 0,022 | Zinc finger protein 443 |
Shown are 42 differentially expressed genes (p-value <0.05 and cut-off 1.3 fold) that are downregulated in Th1Th17 vs. Th1 cells.