Figure 2.

Selective Delta Wave and Spindle Abnormalities during NREM Sleep in E17-MAM Rats

(A) Event triggered averages of raw EEG centered on the negative peaks of the delta waves from motor (left) and visual cortex (right) in SHAM (n = 14, black) and MAM (n = 13, blue) rats. (B) Delta wave densities from the motor and visual cortical EEG electrodes in SHAM and MAM animals. Delta wave density is significantly reduced over the visual cortex in the MAM animals (^∗p < 0.05). Data are taken from the first 2 hr of the animals’ sleep period when slow-wave power is highest. (C and D) Average spindle waveforms (C) and densities (D) recorded over motor (left) and visual (right) cortex showing larger reduction of spindle density at posterior (^∗∗∗p < 0.001) relative to anterior (^∗p < 0.05) sites in MAM animals. (E and F) CA1 ripple waveforms and densities appear normal in MAM animals. All data shown as mean ± SEM. See also Figures S1 and S2.