Fig. 3. Instant SIM reveals ER dynamics at 100 Hz.
A: First image in 200 timepoint series, showing ER labeled with GFP-Sec61A within MRL-TR transformed human lung fibroblasts. Data were acquired at the coverslip surface. Scalebar: 10 μm. b: Higher magnification view of the large white rectangle in a. White arrows mark growth of an ER tubule, blue arrows indicate remodeling of an ER tubule. Scalebar: 5 μm. c: Higher magnification view of the small white rectangle in a, indicating formation of a new tubule within 140 ms. Scale bar: 200 nm. See also Supplementary Video 10.