Table 1. Geometric mean ratios and 90% confidence intervals of rifabutin and 25-O desacetyl rifabutin parameters measured for rifabutin plus lopinavir/ritonavir and rifabutin.

	Rifabutin		25-O desacetyl rifabutin
	150 mg OD	150 mg TPW	150 mg OD	150 mg TPW
Cmax	0.88 (0.75;1.04)	0.65 (0.51;0.83)	2.58 (2.04;3.25)	1.57 (1.21;2.03)
C0	2.61 (2.13;3.19)	0.94 (0.73;1.21)	11.49 (8.21;16.09)	4.35 (3.14;6.02)
AUCτ	1.32 (1.16;1.51)	1.12 (0.92;1.37)	5.13 (3.94; 6.69)	4.74 (3.59; 6.25)
Cave	1.32 (1.16;1.51)	0.56 (0.46;0.69)	5.13 (3.94; 6.69)	2.36 (1.79;3.12)

GMR  =  geometric mean ratio; OD  =  once daily; TPW  =  three times per week; LPV/r  =  lopinavir/ritonavir

AUCτ is AUC_24h for OD and AUC_48h for TPW. Cave is average concentration at steady state calculated as AUCτ/τ, where τ is the dosing interval for RBT, 24 or 48 h