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. 2014 Jan 22;9(1):e84866. doi: 10.1371/journal.pone.0084866

Table 3. Pharmacokinetic parameters of rifabutin and 25-O desacetyl rifabutin.

Rifabutin 25-O desacetyl rifabutin
Alone with lopinavir/ritonavir Alone with lopinavir/ritonavir
300 mg OD 150 mg OD 150 mg TPW 300 mg OD 150 mg OD 150 mg TPW
Cmax ng/mL 792 (344 – 1105) 671 (246 – 1146) 544 (55 – 964) 80 (25 - 595) 216 (94 – 535) 142 (31 – 308)
Tmax h 3 (2 – 4) 3 (2 – 5) 3 (0 – 5) 3 (0 – 5) 4 (2 – 8) 4 (2 – 6)
C0 ng/mL 74 (13 – 161) 180 (121 – 310) 70 (25 – 413) 10 (0 – 595) 137 (48 – 334) 54 (14 – 118)
Cmin ng/mL n = 25 79 (13 – 170) 169 (71 – 320) NA 6 (6 – 329) 115 (59 – 253) NA
Cmin ng/mL n = 15 61 (13 – 118) 161 (71 – 289) 54 (13 – 414) 6 (0 – 33) 114 (73 – 253) 67 (11 – 214)
AUCτ ng.h/mL 5640 (2715–8876) 7292 (3524–12514) 7344 (1426–10896) 697 (245–10250) 4127 (1769–8616) 3807 (872–7628)
Cave ng/mL 235 (113–370) 304 (147–521) 153 (30–227) 29 (10–427) 79 (18–159) 172 (74–359)

Data are presented as medians with the range in parenthesis

OD – once daily; TPW - three times per week; Cmax -peak concentration; Tmax - time to reach peak concentration; C0 - concentration at time 0; Cmin -concentration at the end of a dosing interval (24 h or 48 h);NA non available, Cmin 48 h post dosing non available in 10 patients; AUCτ – area under the curve during a dosing interval τ, τ is 24 h for OD dosing and 48 h for TPW. Cave – average concentration (AUCτ/τ).