Table 1. Multivariate progression and survival analysis in patients with bladder cancer.

Dataset	Endpoint	Clinical variables*	Multivariate analysis (P<0.05)	Final model†
CNUH (N = 165)	Progression	CCP score, stage, grade, BCG therapy, chemotherapy, age, gender	-	CCP score, stage
Lindgren (N = 97)	Progression	CCP score, grade	-	CCP score
Dyrskjot (N = 162)	PFS	CCP score, stage, grade, CIS diagnosis, BCG/MMC treatment, age, gender	CCP score	CCP score
Blaveri (N = 78)	OS	CCP score, grade, stage, surgery, age, gender	CCP score	CCP score
CNUH (N = 165)	DSS	CCP score, stage, grade, BCG therapy, chemotherapy. age gender	Stage, age	Stage, age
Dyrskjot (N = 155)	DSS	CCP score, stage, grade, CIS diagnosis, cystectomy following TURBT, BCG/MMC treatment, age, gender	CCP score, CIS diagnosis	CCP score, CIS, age
Lindgren (N = 156)	DSS	CCP score, stage, grade, cystectomy following TURBT, age, gender	Stage	Stage
MSKCC (N = 87)	OS	CCP score, stage, grade, age, gender	CCP score, stage, grade	Stage, grade

^*Variables include the following (see Tables S6–S7 in File S4 for complete multivariate analysis):

Stage: Ta-T1 vs. T2–T4 (CNUH, Dyrksjot - DSS, Lindgren, and MSKCC) and T1 vs. Ta (Dyrskjot -PFS);

Grade: high vs. low (CNUH, Lindgren, Blaveri, MSKCC); high vs. low vs. PUNLMP (Dyrskjot).

Surgery: cystectomy vs. transurethral resection of the bladder.

Abbreviations: PFS, progression-free survival; OS, overall survival; DSS, disease-specific survival.

^†Final model is constructed from forward step-wise regression of significant variables (P<0.05).