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. 2013 Nov 21;52(4):541–553. doi: 10.1016/j.molcel.2013.09.025

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© 2013 ELL & Excerpta Medica.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

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Alternative Functions of PrimPol in DNA Replication

(A) PrimPol can act as a “conventional” primase but is able to start DNA synthesis on its own.

(B) PrimPol can act as a “classical” TLS polymerase, reading lesions as 8oxoG.

(C) PrimPol can realign the stalled primer terminus ahead of the lesion, acting as a “pseudo” TLS polymerase.

(D) PrimPol can reinitiate DNA synthesis ahead of the lesion, by means of its DNA primase activity, at the single-stranded region generated by continued helix opening after the replicative DNA polymerase got stalled at a lesion. Such a “TLS primase” activity would allow replication fork progression, but a lesion-containing gap would be left behind for later repair.