Table 2. Echocardiographic Parameters in the Study Population Across the rs2270915 Genotype.
| rs2270915 | P Value | |||
| Variable | A/A or A/G (N = 1855) | G/G (N = 76) | Unadjusted | Age/Sex Adjusted |
| Diastolic dysfunction, n (%) | 0.006 | 0.01 | ||
| None | 1216 (72%) | 37 (57%) | ||
| Mild | 321 (19%) | 18 (28%) | ||
| Moderate | 141 (8%) | 9 (14%) | ||
| Severe | 6 (0%) | 1 (2%) | ||
| Diastolic dysfunction, n (%) | 468 (28%) | 28 (43%) | 0.007 | 0.02 |
| Ejection fraction | 63.18±6.47 | 63.20±5.98 | 0.98 | 0.84 |
| LV hypertrophy, n (%) | 161 (11%) | 8 (13%) | 0.65 | 0.87 |
| Deceleration time (msec) | 229.24±38.61 | 242.16±49.84 | 0.005 | 0.01 |
| PA systolic pressure (mmHG) | 22.46±4.78 | 23.60±5.89 | 0.07 | 0.11 |
| LA volume index (mL/m2) | 24.42±7.66 | 25.68±7.59 | 0.19 | 0.36 |
| e' (m/sec) | 0.08 0.04 | 0.08±0.03 | 0.59 | 0.79 |
| e' group, n (%) | 0.07 | 0.13 | ||
| ≤0.07 m/sec | 622 (40%) | 33 (52%) | ||
| >0.07 m/sec | 927 (60%) | 31 (48%) | ||
| E/A ratio | 1.10±0.38 | 1.13±0.51 | 0.49 | 0.24 |
| E/A group, n (%) | 0.58 | 0.48 | ||
| <1 | 642 (35%) | 30 (41%) | ||
| 1–1.5 | 899 (50%) | 32 (44%) | ||
| >1.5 | 271 (15%) | 11 (15%) | ||
| Average LV mass index (g/m2) | 96.04±21.38 | 98.14±21.50 | 0.45 | 0.97 |
| LVESD index (cm/m2) | 1.57±0.25 | 1.57±0.24 | 0.95 | 0.91 |
| LVEDD index (cm/m2) | 2.62±0.29 | 2.65±0.30 | 0.48 | 0.44 |