Table 3A.
Comparison of Leptin, Adiponectin and Insulin Levels Between BE Patients and Controls and Relative Risk of BE.
| Cases (n=141) | Controls (n=139) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | |
|---|---|---|---|---|
| Leptin | ||||
| Median (IQR) | 12,902 (4,615–42,997) | 5,232 (2,634–3,808) | ||
| Q 1 (Lowest-3154) | 24 (17.0%) | 39 (28.1%) | Ref | Ref |
| Q 2 (3154–5377) | 17 (12.1%) | 34 (24.5%) | 0.81 (0.38–1.76) | 1.12 (0.43–2.90) |
| Q 3 (5377–12629) | 26 (18.4%) | 28 (20.1%) | 1.51 (0.72–3.15) | 2.53 (0.99–6.43) |
| Q 4 (12629–33904) | 35 (24.8%) | 22 (15.8%) | 2.59 (1.237–5.401) | 3.96 (1.56–10.01) |
| Q 5 (33904-Highest) | 39 (27.7%) | 16 (11.5%) | 3.96 (1.84–8.58) | 8.02 (2.79–23.07) |
| p Values* | <0.001 | <0.001 | ||
| Adiponectin | ||||
| Median (IQR) | 7.02 (3.79–11.75) | 5.71 (3.32–9.16) | ||
| Q 1 (Lowest-3.20) | 21 (19.4%) | 32 (23.0%) | Ref | Ref |
| Q 2 (3.20–5.258) | 18 (16.7%) | 30 (21.6%) | 0.91 (0.41–2.04) | 1.11 (0.42–2.93) |
| Q 3 (5.258–8.203) | 25 (23.2%) | 31 (22.3%) | 1.23 (0.57–2.63) | 1.77 (0.69–4.54) |
| Q 4 (8.203–12.713) | 23 (21.3%) | 27 (19.4%) | 1.30 (0.59–2.84) | 2.62 (0.99–6.91) |
| Q 5 (12.713-Highest) | 21 (19.4%) | 19 (13.7%) | 1.68 (0.74–3.86) | 1.49 (0.54–4.11) |
| p Values* | 0.15 | 0.65 | ||
| Insulin (non-diabetics) | ||||
| Median (IQR) | 470.4 (270.2–887.0) | 440.02 (209.3–716.9) | ||
| Q 1 (Lowest-210) | 21 (17.4%) | 28 (25.3%) | Ref | Ref |
| Q 2 (210–390) | 27 (22.3%) | 23 (20.7%) | 1.57 (0.71–3.46) | 1.43 (0.57–3.64) |
| Q 3 (390–579) | 21 (17.4%) | 23 (20.7%) | 1.217 (0.537–2.76) | 1.02 (0.38–2.75) |
| Q 4 (579–921) | 23 (19.0%) | 20 (18.0%) | 1.53 (0.67–3.50) | 0.79 (0.30–2.07) |
| Q 5 (921-Highest) | 29 (24.0%) | 17 (15.3%) | 2.275 (0.998–5.18) | 2.06 (0.78–5.46) |
| p Values* | 0.081 | 0.363 |
Median levels for all biomarkers are shown in pg/mL.
*
Goodness-of-fit to marginal frequencies was tested by χ2 (p values in rightmost column); Kendall’s tau-b (p for trend) in second-right column, for the unadjusted analyses and logistic-regression models, adjusting for age, sex, race, waist-hip ratio, current use of proton pump inhibitors, use of nonsteroidal anti-inflammatory drugs, and H. pylori for the adjusted analyses.
indicates a p value <0.05 using the Mann-Whitney U statistic.