Table 3B.
Comparison of Leptin, Adiponectin and Insulin Levels between BE Patients and Controls and Relative Risk of BE in White Men Only.
| Cases (n=122) | Controls (n=87) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | |
|---|---|---|---|---|
| Leptin | ||||
| Median (IQR) | 13,091 (4,668–43,675) | 4,979 (3,155–11,382) | ||
| Q 1 (Lowest-3154) | 20 (16.4%) | 21 (24.1%) | Ref | Ref |
| Q 2 (3154–5377) | 15 (12.3%) | 27 (31.0%) | 0.58 (0.24–1.41) | 0.65 (0.22–1.91) |
| Q 3 (5377–12629) | 22 (18.0%) | 20 (23.0%) | 1.16 (0.49–2.73) | 1.66 (0.57–4.87) |
| Q 4 (12629–33904) | 31 (25.4%) | 11 (12.6%) | 2.96 (1.18–7.43) | 4.42 (1.48–13.18) |
| Q 5 (33904-Highest) | 34 (27.9%) | 8 (9.2%) | 4.46 (1.67–11.94) | 10.99 (2.90–41.61) |
| p Values* | <0.001 | <0.001 | ||
| Adiponectin | ||||
| Median (IQR) | 7.42 (3.8–12.2) | 5.61 (3.3–9.2) | ||
| Q 1 (Lowest-3.20) | 16 (17.4%) | 20 (23.0%) | Ref | Ref |
| Q 2 (3.20–5.258) | 15 (16.3%) | 20 (23.0%) | 0.94 (0.37–2.40) | 1.34 (0.44–4.08) |
| Q 3 (5.258–8.203) | 20 (21.7%) | 17 (19.5%) | 1.47 (0.59–3.70) | 1.71 (0.57–5.09) |
| Q 4 (8.203–12.713) | 20 (21.7%) | 16 (18.4%) | 1.56 (0.62–3.96) | 3.27 (1.06–10.05) |
| Q 5 (12.713-Highest) | 21 (22.8%) | 14 (16.1%) | 1.88 (0.73–4.82) | 2.30 (0.72–7.33) |
| p Values* | 0.10 | 0.54 | ||
| Insulin (non-diabetics) | ||||
| Median (IQR) | 473.1 (275.0–872.8) | 450.2 (217.8–823.1) | ||
| Q 1 (Lowest-210) | 18 (17.1%) | 17 (24.3%) | Ref | Ref |
| Q 2 (210–390) | 21 (20.0%) | 14 (20.0%) | 1.42 (0.55–3.65) | 1.48 (0.48–4.54) |
| Q 3 (390–579) | 20 (19.0%) | 15 (21.4%) | 1.26 (0.49–3.23) | 1.13 (0.36–3.48) |
| Q 4 (579–921) | 22 (21.0%) | 13 (18.6%) | 1.60 (0.62–4.15) | 1.17 (0.38–3.62) |
| Q 5 (921-Highest) | 24 (22.9%) | 11 (15.7%) | 2.06 (0.78–5.46) | 2.23 (0.68–7.30) |
| p Values* | 0.15 | 0.67 |
Median levels for all biomarkers are shown in pg/mL.
*
Goodness-of-fit to marginal frequencies was tested by χ2; p values were calculated using Kendall’s tau-b (p for trend) for the unadjusted analyses and logistic-regression models, adjusting for age, sex, race, waist-hip ratio, current use of proton pump inhibitors, use of nonsteroidal anti-inflammatory drugs, and H. pylori for the adjusted analyses.
#
indicates a p value <0.05 using the Mann-Whitney U statistic.