Figure 1. Interactions between the nuclear pore complex and inducible genes. (A) In S. cerevisiae, inducible genes move from the nuclear interior to the NPC upon activation, mediated by the SAGA and TREX complexes. Genes can stay at the NPC during short-term repression, allowing for fast activation, but move toward the interior under long-term repression. (B) In S. pombe, inducible genes are bound by the transcriptional regulator Atf1 and associate with the NPC. Under repressive conditions, the RNAi machinery degrades the transcripts coming from these genes, keeping mRNA levels low. When induced, Atf1 gets phosphorylated and leads to increased transcription, overcoming the degradation of transcripts through RNAi.