Table 1. The characteristics of patients with cervical cancer and cancer-free controls.
| Study 1 | Study 2 | All | subjects | ||||||
| Characteristics | Controls (n = 334) | Cases (n = 338) | P b | Controls (n = 600) | Cases (n = 502) | P | Controls (n = 934) | Cases (n = 840) | P |
| Age a , year (Mean±SD) | 47.2±10.8 | 46.5±8.7 | 0.355 | 48.4±11.2 | 47.5±9.5 | 0.262 | 48.0±11.1 | 47.1±9.2 | 0.065 |
| Race, n (%) | |||||||||
| Han Chinese | 290 (86.8) | 285 (84.3) | 0.355 | 538 (89.7) | 453 (90.2) | 0.753 | 828 (88.7) | 738 (87.9) | 0.604 |
| Hui Chinese | 44 (13.2) | 53 (15.7) | 62 (10.3) | 49 (9.8) | 106 (11.3) | 102 (12.1) | |||
| Smoking | |||||||||
| Never | 305 (91.3) | 313 (92.6) | 0.540 | 562 (93.7) | 448 (89.2) | 0.008 | 867 (92.8) | 761 (90.6) | 0.088 |
| Ever | 29 (8.7) | 25 (7.4) | 38 (6.3) | 54 (10.8) | 67 (7.2) | 79 (9.4) | |||
| Education | |||||||||
| JHS and below | 189 (56.6) | 201 (59.5) | 0.550 | 314 (52.3) | 282 (56.2) | 0.717 | 503 (53.9) | 483 (57.5) | 0.488 |
| SHS and above | 145 (43.4) | 137 (40.5) | 286 (47.7) | 220 (43.8) | 431 (46.1) | 357 (42.5) | |||
| Age at primiparity | |||||||||
| ≤24 years | 206 (63.6) | 219 (66.6) | 0.424 | 390 (67.0) | 365 (73.1) | 0.031 | 596 (65.8) | 575 (70.5) | 0.038 |
| >24 years | 118 (36.4) | 110 (33.4) | 192 (33.0) | 131 (26.9) | 310 (34.2) | 241 (29.5) | |||
| Missing or nulliparous | 10 | 9 | 18 | 15 | 28 | 24 | |||
| Marital status | |||||||||
| Never married | 6 (1.9) | 4 (1.2) | 0.195 | 15 (2.7) | 11 (2.3) | 0.145 | 21(2.4) | 15 (1.8) | 0.035 |
| Married only once | 259 (83.5) | 264 (79.3) | 453 (80.3) | 370 (76.0) | 712 (81.5) | 634 (77.4) | |||
| ≥2 times | 45 (14.5) | 65 (19.5) | 96 (17.0) | 106 (21.7) | 141 (16.1) | 171 (20.9) | |||
| Missing | 24 | 5 | 36 | 15 | 60 | 20 | |||
| HPV infection status | |||||||||
| HPV + | 106 (31.7) | 296 (87.6) | <0.001 | 229 (38.2) | 420 (83.7) | <0.001 | 335 (35.9) | 716 (85.2) | <0.001 |
| HPV - | 228 (68.3) | 42 (12.4) | 371 (61.8) | 82 (16.3) | 599 (64.1) | 124 (14.8) | |||
| Clinical stage c | |||||||||
| I | 247 (73.1) | 365 (72.7) | 612 (72.9) | ||||||
| II | 69 (20.4) | 118 (23.5) | 187 (22.3) | ||||||
| II I/IV | 22 (6.5) | 19 (3.8) | 41 (4.9) | ||||||
| Histology | |||||||||
| SC | 280 (82.8) | 398 (79.3) | 678 (80.7) | ||||||
| Adenocarcinoma | 44 (13) | 75 (14.9) | 119 (14.2) | ||||||
| Other | 14 (4.1) | 29 (5.8) | 43 (5.1) |
a
Age of diagnosis for cases and age when they participated in this study for controls.
b
Statistically significant results with an FPRP value <0.2 are marked in bold.
c
Based on International Federation of Gynecology and Obstetrics classification system.
Abbreviation: SD, standard deviation; JHS, junior high school; SHS, senior high school; SC: Squamous carcinoma.