Table 3. Association of the selected SNPs from the Study 1 and an additional SNP in IL-16 with the risk for cervical cancer in the Study 2.
| Study 2 | Combined Study 1and 2 | |||||||||||
| Variant | Genotype | Controls | Cases | Logistic regression | Controls | Cases | Logistic regression | |||||
| (n = 600) No. (%) | (n = 502) No. (%) | P value (2df)a | Adjusted OR (95%CI) | P valueb | (n = 934) No. (%) | (n = 840) No. (%) | P value (2df)a | Adjusted OR (95%CI) | P valueb | |||
| REV3L | AA | 432 (72.0) | 353 (70.6) | 0.741 | 1.00 (referent) | 657 (70.4) | 606 (72.5) | 0.599 | 1.00 (referent) | |||
| rs465646 | AG | 153 (25.5) | 131 (26.2) | 1.05 (0.8∼1.38) | 0.737 | 251 (26.9) | 211 (25.2) | 0.91 (0.74∼1.12) | 0.392 | |||
| GG | 15 (2.5) | 16 (3.2) | 1.31 (0.64∼2.69) | 0.466 | 25 (2.7) | 19 (2.3) | 0.82 (0.45∼1.51) | 0.532 | ||||
| AG+GG | 168 (28.0) | 147 (29.4) | 1.07 (0.82∼1.39) | 0.609 | 276 (29.6) | 230 (27.5) | 0.91 (0.73∼1.11) | 0.334 | ||||
| BIRC5 | TT | 353 (58.8) | 277 (55.3) | 0.199 | 1.00 (referent) | 559 (60) | 460 (55) | 0.008 | 1.00 (referent) | |||
| rs2239680 | TC | 215 (35.8) | 185 (36.9) | 1.10 (0.86∼1.41) | 0.473 | 331 (35.5) | 312 (37.3) | 1.14 (0.94∼1.40) | 0.179 | |||
| CC | 32 (5.3) | 39 (7.8) | 1.56 (0.95∼2.55) | 0.079 | 42 (4.5) | 64 (7.7) | 1.85 (1.23∼2.79) | 0.004 | ||||
| TC+CC | 247 (41.2) | 224 (44.7) | 1.16 (0.91∼1.47) | 0.236 | 373 (40) | 376 (45) | 1.22 (1.01∼1.47) | 0.035 | ||||
| FGF2 | TT | 452 (75.3) | 401 (79.9) | 0.166 | 1.00 (referent) | 729 (78.2) | 660 (78.6) | 0.018 | 1.00 (referent) | |||
| rs1476215 | TA | 134 (22.3) | 89 (17.7) | 0.75 (0.55∼1.01) | 0.059 | 184 (19.7) | 145 (17.3) | 0.98 (0.78∼1.23) | 0.26 | |||
| AA | 14 (2.3) | 12 (2.4) | 0.97 (0.44∼2.12) | 0.933 | 19 (2) | 35 (4.2) | 0.87 (0.68∼1.11) | 0.012 | ||||
| TA+AA | 148 (24.7) | 101 (20.1) | 0.77 (0.57∼1.03) | 0.071 | 203 (21.8) | 180 (21.4) | 2.03 (1.15∼3.58) | 0.858 | ||||
| E2F1 | GG | 325 (54.2) | 277 (55.2) | 0.869 | 1.00 (referent) | 503 (54) | 431 (51.3) | 0.104 | 1.00 (referent) | |||
| rs3213180 | GC | 224 (37.3) | 180 (35.9) | 0.95 (0.73∼1.22) | 0.650 | 352 (37.8) | 315 (37.5) | 1.04 (0.85∼1.27) | 0.669 | |||
| CC | 51 (8.5) | 45 (9.0) | 1.03 (0.68∼1.59) | 0.872 | 77 (8.3) | 94 (11.2) | 1.42 (1.02∼1.97) | 0.032 | ||||
| GC+CC | 275 (45.8) | 225 (44.8) | 0.96(0.76∼1.21) | 0.735 | 429 (46) | 409 (48.7) | 1.11 (0.92∼1.34) | 0.264 | ||||
| IL16 | TT | 243 (40.5) | 156 (31.1) | 0.002 | 1.00 (referent) | 369 (39.5) | 256 (30.5) | 0.00004 | 1.00 (referent) | |||
| rs1131445 | TC | 284 (47.3) | 258 (51.4) | 1.42 (1.09∼1.85) | 0.008 | 453 (48.5) | 438 (52.1) | 1.40 (1.14∼1.72) | 0.0014 | |||
| CC | 73 (12.2) | 88 (17.5) | 1.88 (1.31∼2.73) | 0.0006 | 112 (12) | 146 (17.4) | 1.88 (1.4∼2.52) | 0.00002 | ||||
| TC+CC | 357 (59.5) | 346 (68.9) | 1.51(1.18∼1.93) | 0.001 | 565 (60.5) | 584 (69.5) | 1.49 (1.22∼1.81) | 0.00007 | ||||
a
P value was calculated using a χ2 test with 2 d.f.
b
Adjusted for age, smoking status, education level, age at primiparity, marital status, and HPV infection status. Bold characters indicate the corresponding P values, and the ORs were statistically significant after considering FPRP.
Abbreviations: CI, confidence interval; OR, odds ratio.