Figure 4. KFD-p24 3D induced a lowered systemic inflammatory response after intra-nasal administration. Control protein p24 (10μg) or recombinant flagellin with PBS (10 μl) was administrated intranasally to BALB/c mice. Time- course of (A) IL-6, (B) KC and (C) TNF-α in BALFs after administration. IL-6 and KC in serum (D) and nose lavage fluid (E) 4 h after administration. (F) Body mass changes after administration. Data are presented as the means ± SEM from one experiment that was repeated three times (n = 6 per group).