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. 2013 Jan 31;9(5):993–1001. doi: 10.4161/hv.23800

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Copyright © 2013 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name hvi-9-993-g1.jpg — Figure 1. HIV-1 expression in U1 and ACH2 cells treated with HDAC inhibitors. HIV-1 expression in U1 and ACH2 cells treated with panobinostat (LBH589), belinostat (PXD101), givinostat (ITF2357), vorinostat (SAHA) and valproic acid (VPA) for 48 h; median +/− IQR p24 concentrations of 15 (ACH2) and 8 (U1) separate experiments in each cell line are depicted in graphs A and B. Comparison of median +/− IQR induced viral production with indicated concentrations of LBH589 or SAHA is shown in C and D. Capped lines above error bars indicate the range of therapeutic plasma levels for each HDAC inhibitor. Dotted line indicates p24 levels in untreated cells.