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. 2013 Aug 5;12(17):2738–2743. doi: 10.4161/cc.25746

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Figure 2. AKT radioresponse after 31-d FR. AKT pro-survival signals accumulate during exposure to FR. When these signals cross a threshold, the AKT response is changed from transient activation to constitutive activation after irradiation. Cyclin D1 is overexpressed in 31FR cells in which AKT is constitutively activated because of cumulative AKT pro-survival signals.